Hot Paper - Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy

Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy

在实体瘤中分散接种 CAR T 细胞可增强抗癌功效
固形腫瘍におけるCART細胞の散在播種は、抗癌効果を増強します
고형 종양에 CAR T 세포를 흩뿌리면 항암 효과가 증가합니다
La siembra dispersa de células CAR T en tumores sólidos aumenta la eficacia contra el cáncer
L'ensemencement dispersé de cellules CAR T dans les tumeurs solides augmente l'efficacité anticancéreuse
Рассеивание CAR-Т-клеток в солидных опухолях повышает противоопухолевую эффективность

Hongjun Li 李洪军 ¹ ² ³ ⁴ ⁵, Zejun Wang 王则君 ³ ⁴ ⁵, Edikan Archibong ⁶ ⁷, Qing Wu ¹, Guojun Chen 陈国军 ³ ⁴ ⁵, Quanyin Hu ⁷, Tianyuan Ci 慈天元 ³ ⁴ ⁵, Zhaowei Chen 陈兆委 ¹ ³ ⁴ ⁵, Jinqiang Wang 王金强 ¹ ³ ⁴ ⁵, Di Wen 温迪 ³ ⁴ ⁵, Hongwei Du 杜红伟 ⁶ ⁷, Jie Jiang ⁸, Jie Sun 孙洁 ⁸, Xingcai Zhang 张兴才 ⁹, Gianpietro Dotti ⁶ ⁷, Zhen Gu 顾臻 ¹ ² ³ ⁴ ⁵

¹ College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
中国杭州浙江大学药学院
² Liangzhu Laboratory, Zhejiang University Medical Center, Sir Run Run Shaw Hospital,
Hangzhou 310058, China
中国杭州邵逸夫医院浙江大学医学中心良渚实验室
³ Department of Bioengineering, University of California, Los Angeles, CA 90095 USA
⁴ Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095 USA
⁵ California NanoSystems Institute, University of California, Los Angeles, CA 90095 USA
⁶ Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA
⁷ Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
⁸ Department of Cell Biology and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China
中国杭州浙江大学医学院附属第一医院骨髓移植中心
⁹ John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA

https://doi.org/10.1093/nsr/nwab172

https://academic.oup.com/nsr/advance-article/doi/10.1093/nsr/nwab172/6373459

National Science Review, 21 September 2021

Abstract

Chimeric antigen receptor T cell (CAR T) therapy reached a milestone in the treatment of relapsed and refractory B-cell malignancies. However, beneficial effects of CAR T cells have not been obtained in solid tumors yet. Herein, we implemented a porous microneedle patch that accommodates CAR T cells and allows in situ penetration-mediated seeding of CAR T cells when implanted in the tumor bed or in post-surgical resection cavity.

CAR T cells loaded in the pores of the microneedle tips were readily escorted to the tumor in an evenly scattered manner without losing their activity. Such microneedle-mediated local delivery enhanced infiltration and immunostimulation of CAR T cells as compared to direct intratumoral injection. This tailorable patch offers a transformative platform for scattered seeding of living cells for treating a variety of tumors.

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