3D printing of bioinspired compartmentalized capsular structure for controlled drug release
用于控制药物释放的仿生隔室胶囊结构的 3D 打印
制御された薬物放出のためのバイオインスパイアードコンパートメント化された莢膜構造の3D印刷
제어된 약물 방출을 위한 생체 영감 구획 캡슐 구조의 3D 프린팅
Impresión 3D de una estructura capsular compartimentada bioinspirada para una liberación controlada del fármaco
Impression 3D d'une structure capsulaire compartimentée bioinspirée pour une libération contrôlée de médicament
3D-печать биоинспирированной капсульной структуры для контролируемого высвобождения лекарств
Jingwen LI 李静雯 ¹, Mingxin WU 武明信 ², Wenhui CHEN ¹, Haiyang LIU 刘海洋 ¹, Di TAN 谭迪 ¹, Shengnan SHEN 申胜男 ¹, Yifeng LEI 雷祎凤 ², Longjian XUE 薛龙建 ¹
¹ School of Power and Mechanical Engineering, Wuhan University, Wuhan 430072, China
中国 武汉 武汉大学动力与机械学院
² The Institute of Technological Science, Wuhan University, Wuhan 430072, China
中国 武汉 武汉大学工业科学研究院
Journal of Zhejiang University Science B, 14 December 2021
Abstract
Drug delivery with customized combinations of drugs, controllable drug dosage, and on-demand release kinetics is critical for personalized medicine. In this study, inspired by successive opening of layered structures and compartmentalized structures in plants, we designed a multiple compartmentalized capsular structure for controlled drug delivery.
The structure was designed as a series of compartments, defined by the gradient thickness of their external walls and internal divisions. Based on the careful choice and optimization of bioinks composed of gelatin, starch, and alginate, the capsular structures were successfully manufactured by fused deposition modeling three-dimensional (3D) printing. The capsules showed fusion and firm contact between printed layers, forming complete structures without significant defects on the external walls and internal joints. Internal cavities with different volumes were achieved for different drug loading as designed.
In vitro swelling demonstrated a successive dissolving and opening of external walls of different capsule compartments, allowing successive drug pulses from the capsules, resulting in the sustained release for about 410 min. The drug release was significantly prolonged compared to a single burst release from a traditional capsular design. The bioinspired design and manufacture of multiple compartmentalized capsules enable customized drug release in a controllable fashion with combinations of different drugs, drug doses, and release kinetics, and have potential for use in personalized medicine.